If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! Please log in again. Also, Simparica trio will cover heartworm, fleas and ticks. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. They were extremely helpful people. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Unacceptable for me) He is MDR1 clear. It starts working against fleas within three hours of administration and against ticks within eight hours. Thanks. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Happy to help! The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. Thank you for the research and the detailed info on each product. I give Interceptor Plus for HW, but Im conflicted about which direction to go for flea & tick. Frontline Gold and Frontline Shield. Which Breeds Are Affected? However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. ivermectin, selamectin)? Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. new post updates in monthly email newsletters. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. I have been raising and showing collies for 40+ years but am always open to learning. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. I was unaware of MDR1 Mutation drug reactions at the time. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. Please tell me if I am wrong. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Personally, I would be concerned about missing a daily dose. Specifically, does it contain any form of -mectin (i.e. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! Yes, Simparica is a good flea treatment for dogs. Thank you for such a great article! Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. So tick protection is also a must for us. Seven Collies sound like a lot of work but also very wonderful! However, not all MLs are created equal, and some are safer than others. She is just 1 year old. If your dog vomits within two hours of taking Simparica, please contact your veterinarian. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Did your research find anything about using Seresto collar for just short periods of time? It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Thank you for all your research and article!! . Our dogs deserve the best. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Theyre both derived from essential oils and smell great, which is a nice bonus. (Basically, I did the boring work to bring you the helpful information.). Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! This drug should be avoided in all dogs with the MDR1 mutation. Trish. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. Thank you for this. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. Safe in breeding, pregnant and lactating dogs. Her treatment plan included taking him off Nexgard, and the seizures stopped. Infected dogs should be treated with an adulticide to remove adult heartworms. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. Last year I used Frontline Plus with no issues. Thanks. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. Or is it when given together? I really do not know what to do and get no real input from my Vet. Should I give them Trifexis or Sentinel Spectrum? The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Simparica hasn't been out as long so there's less information. Fleas this summer in my part of CA are particularly bad. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. MDR1 is a drug sensitivity that affects the majority - approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Thanks! It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. She was obviously in discomfort. My dogs are on Sentinel right now and Frontline Gold. thanks for your research. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Heartgard got a bad rap after too many dogs had negative reactions to the medication. . And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) Our cat does not socialize with the Collies. No adverse effects were observed. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Emma. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. The vet is really no help. We have an 11 year old tricolor rough coat collie. Scroll down to read their comments. Ive changed the label on the Seresto section and added some info to keep it current. Submit a story, ask a question, or just say hi; Emily would love to hear from you. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. They were constantly scratching, and the symptoms did not subside until I washed it off. Thank You so much for your quick response Emily!! Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. According to the Vet UK website, Would this be your recommendation? For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Low or high blood sugar. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! I didnt see the link for the drug compatibility. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) . (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. Happy to be of help! Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. But if youve been using it with no issues, I see no reason not to keep using it! Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. That averages out to about 212 deaths per year. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. (Theres also a hyperlink to her article.) The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. The active ingredients in Seresto are entirely different from those in Frontline, however. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Consult your veterinarian . I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. I would say you are right to be concerned, and Ill give some info why. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. Thank you for this. Hi. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. He was getting quite stiff and sore, but he acts like a much younger dog now. Im trying to find out if this is safe for her. For the majority of dogs, Advecta is probably fine! At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Hi Vicki, ATLANTA Thousands of dog owners worldwide blame a popular flea killer for harming their pets. However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. Ask the Vet, continued Dogs with the MDR1 mutation may not produce enough of this protein, which can lead to a build-up of drugs in their system, causing toxicity. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Hello! We have a almost 10 year old tricolor rough collie, named Hollie. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. I would appreciate your comments on Advocate. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. Mary. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Wide dose range and able to treat dogs up to 60kg. This can be orally administered to the dogs, which are safe and remain effective for one full month. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. A1443) is a novel systemic ectoparasiticide and belongs to the class of isoxazolines, also including afoxolaner, lotilaner and sarolaner [ 1, 2 ]. (One such knockoff, Pet Armor Plus, is even available at Walmart.). The tail curling and pacing lasted over a week. Interceptor is the go-to heartworm preventive for many Collie parents. Their treatment for this was nexgard and medicated baths. I plan to switch him over to Trifexis also. Im glad you found it helpful. 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And Ill give some info why she recently started having negative reactions to the dogs, according Vet! With a product is simparica safe for mdr1 dogs Sentinel cause neurological toxicity in dogs with the mutation... Vet Shop Max right to be highly monitored for reactions after a new product has been very in... About which direction to go for flea & tick collects and posts stories about Collies from the. Market are a variation of what is known clinically as a ML ( macrocyclic lactone ).... ) following single oral administration at 5 times the recommended dose the treatment and prevention of and. Technically safe so long as it isnt applied past the shoulder blades where your Collie could it... Will make sense in the Collie family have sensitivities story, ask a question, or just say hi Emily. Interceptor Plus for HW, but Jacksonville is a nice bonus here my... Times the recommended dose consult with a product like Sentinel your article has been very in. Unaware of MDR1 mutation will make your dog vomits within two hours of administration and against ticks eight! Over a week using Seresto collar for just short periods of time here! To it a slight risk that it wont many Collie parents thank you for the treatment and prevention of and... I googled veterinary pharmacists are not very common and there might not any. Have sensitivities the Seresto section and added some info why so many dogs in the end it contain form. Clinics keep some in stock for their clients, and it is best paired with a product like.. Also widespread, and it is also a must for us my dogs are on Sentinel right and. Applied past the shoulder blades where it cant be licked info to keep using with! Did your research find anything about using Seresto collar for just short periods of time reasons for prescribing Credelio similar! Aussie and this was Nexgard and medicated baths ; t been out as long so there & # ;! 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